Fox-Fordyce Disease is a rare disorder that occurs almost solely in women. It is characterized by the development of intense itching usually in the underarm area, the pubic area, and around the nipple of the breast. Perspiration becomes trapped in the sweat gland and in the surrounding area causing intense itching, inflammation, and enlargement of the glands. Skin in the area may become darkened and dry; raised patches develop. Hair follicles in the area dry out resulting in loss or breakage of hair.
Fox-Fordyce disease is a chronic skin disease most common in women aged 13-35 years. It is characterized by the development of intense itching in the underarm area, the pubic area, and around the nipple of the breast as a result of perspiration which becomes trapped in the sweat gland and surrounding areas. The cause is unknown, but heat, humidity, and stress appear to be exacerbating factors. Retinoids, antibiotics, and immunosuppressants have had limited success in controlling the symptoms.