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Subcortical spongy changes of the white
matter. The cortex above is spared. The dark stained neurons are not affected. |
Canavan Disease
Canavan disease (CD) is an inherited (genetic) disease. It occurs due to a deficiency of
the enzyme called Aspartoacylase, since the gene which usually tells the body to produce
this enzyme is faulty. Babies are born apparently unaffected. At 2 to 4 months of age,
he/she develops poor head control and seizures.
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